This methylation profile is by now obtained with the MBL stage3 and continues to be reasonably secure as time passes. On the other hand, some CLL have intratumor variability in specified locations, which may alter the expression of numerous genes and aid tumor evolution.seventy one Of Observe, this variability is bigger in U-CLL than in M-CLL and is linked to expanding quantity of subclones.seven,seventy one

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